Gwill has spent the last 20 years in a variety of positions in the venture capital community, the last 17 focused exclusively on structured venture capital investing. She directs the firm's East Coast investment activities, and oversees investment decision making, fundraising, and other operational activities for the Funds. While at Lighthouse she has led the firm's investments in NxStage Medical, Millennium Pharmaceuticals, DataSage, Sirocco Systems, Corvis, Triton, Ontogeny, StorageNetworks, and Bolt Media.

Prior to co-founding Lighthouse in June 1994, Gwill was a Senior Vice President with Comdisco Ventures where she directed and managed East Coast investment activities. She joined Comdisco Ventures in 1988 having been recruited to establish its East Coast presence. While at Comdisco, she led the firm's investments in over 50 companies, primarily in the biotechnology and communications equipment areas including Human Genome Sciences, Millennium Pharmaceuticals, Vertex Pharmaceuticals, Cascade Communications, Appex, and Brooktrout Technologies.

Gwill holds an AB in economics from Harvard University and an MBA from the Harvard Business School.